Effect of Intravenous Dexmedetomidine on the Action of Spinal Bupivacaine in Comparision with Intravenous Midazolam Authors

1 Associate Professor, 2* Assistant Professor, 3 Post Graduate, 4 Professor: Department of Anesthesiology, Gandhi Medical College, Padmarao Nagar, Secunderabad, Telangana *Corresponding Author Dr .D. Suresh Chander Associate Professor, Dept of Anesthesiology, Gandhi Medical College, Padmarao Nagar, Secunderabad, Email: [email protected] ABSTRACT Background: The present study was designed to evaluate the effect of intravenous dexmedetomidine on the action of spinal bupivacaine in comparision with intravenous midazolam. Materials and methods: Study was done for a period of 8 months in total 50 patients, first group are of 25 patients receiving intravenous Dexmedetomidine 0.5 micrograms/kg (n = 25). The second group are controls of 25 patients receiving intravenous midazolam 0.05milligrams/kg (n = 25). Results: Duration of sensory blockade and motor blockade was prolonged with the use of intravenous dexmedetomidine premedication in comparison with intravenous midazolam. Good sedation levels, patient’s cooperation and better operating conditions for the surgeon without significant respiratory depression were achieved, intra operative risk of bradycardia was more clear and significant with dexmedetomidine than with midazolam. Post operative analgesia was significantly prolonged with the use of intravenous dexmedetomidine premedication than with intravenous midazolam. Conclusion: Supplementation of spinal anesthesia with intravenous dexmedetomidine produces significantly longer sensory and motor block than intrathecal bupivacaine alone